Calls for greater data sharing and transparency in clinical research have intensified in recent years. The potential benefits of data sharing are multifaceted. Increased data transparency can allow research findings to be independently verified; be a valuable resource to address multiple secondary questions; allow combinations with other study data, thereby enabling meta-analytic insights; and facilitate better planning of future research. Data sharing is also consistent with the fundamental principle that science should be a collaborative process used to its maximal common benefit.