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Comment & Response
October 2018

Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction—Reply

Author Affiliations
  • 1Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 3Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 4University of Pittsburgh Medical Center Heart and Vascular Institute, Pittsburgh, Pennsylvania
  • 5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
JAMA Cardiol. 2018;3(10):1023-1024. doi:10.1001/jamacardio.2018.1936

In Reply We appreciate the comments from Cao concerning our article.1 We originally used a left ventricular ejection fraction cut point of 45% or greater. As pointed out by Cao, current guidelines use 50% or greater.2,3 Reanalyzing our data using a left ventricular ejection fraction of 50% or greater, we found 220 fewer patients (decreasing from 2587 of 10 023 [25.8%] to 2367 [23.6%]) classified with pulmonary hypertension (PH) in the setting of heart failure with preserved ejection fraction (PH-HFpEF). Based on this very minimal change, there were no significant changes in any of our results. For the sake of clarity, we report here some of the minor changes.

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