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Comment & Response
March 27, 2019

Quantifying the Treatment Effect of Drug-Eluting Stents Optimized for Biocompatibility vs Bare-Metal Stents With a Single Month of Dual Antiplatelet Therapy—Reply

Author Affiliations
  • 1Veterans Affairs Medical Center, Memphis, Tennessee
  • 2Section of Cardiovascular Medicine, School of Medicine, University of Tennessee, Memphis
  • 3Duke Clinical Research Institute, Durham, North Carolina
  • 4Piedmont Heart Institute, Atlanta, Georgia
JAMA Cardiol. 2019;4(5):494-495. doi:10.1001/jamacardio.2019.0556

In Reply We appreciate the thoughtful letter by Zemplenyi and Wei about our article.1 They propose our analysis should have used risk differences (RDs) instead of odds ratios (ORs) for pooled estimates. The appropriate summary statistic for meta-analysis has been highly debated in the literature.2 However, per Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, use of any of 3 summary statistics (ie, OR, risk ratio [RR], or RD) is appropriate for binary outcomes.3

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