Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of death in the United States.1 Elevated low-density lipoprotein cholesterol (LDL-C) level is a major risk factor for ASCVD. Randomized clinical trials of patients without ASCVD demonstrate that lowering LDL-C levels reduces risk for future cardiovascular events. Statins are primary drugs for reducing LDL-C levels. This document reviews evidence-based strategies to reduce LDL-C levels in primary prevention.