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JAMA Cardiology Clinical Guidelines Synopsis
April 10, 2019

2018 American Heart Association/American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol: Primary Prevention

Author Affiliations
  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
  • 2Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA Cardiol. 2019;4(5):488-489. doi:10.1001/jamacardio.2019.0777

Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of death in the United States.1 Elevated low-density lipoprotein cholesterol (LDL-C) level is a major risk factor for ASCVD. Randomized clinical trials of patients without ASCVD demonstrate that lowering LDL-C levels reduces risk for future cardiovascular events. Statins are primary drugs for reducing LDL-C levels. This document reviews evidence-based strategies to reduce LDL-C levels in primary prevention.

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