In Reply Weller inquires about the contribution of recent trials and updated meta-analyses of vitamin D and cardiovascular disease (CVD). In our recent meta-analysis,1 we included more than 21 randomized clinical trials, including the Vitamin D and Omega-3 Trial (VITAL)2 and the Vitamin D Assessment trial (VIDA),3 which are 2 of the largest trials that prespecified CVD as a primary or coprimary end point. Most previous trials had tested lower doses of vitamin D and assessed CVD only as a post hoc outcome. Thus, it was very important to have an updated meta-analysis including these and other recent trials.
Barbarawi M, Barbarawi O, Manson JE. Beneficial Effects of Sunlight May Account for the Correlation Between Serum Vitamin D Levels and Cardiovascular Health—Reply. JAMA Cardiol. Published online November 13, 2019. doi:https://doi.org/10.1001/jamacardio.2019.4342
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