In Reply We appreciate the correspondence brought forward by Sutanto et al, who support our work1 and facilitate further fruitful discussion of the study. To address the first point regarding markers of inflammation in psoriasis, although C-reactive protein (CRP) is less specific, we used a high-sensitivity assay. High-sensitivity CRP is an independent predictor of future myocardial infarction and stroke beyond cholesterol.2 Moreover, although interleukin 18, tumor necrosis factor α, and pentraxin have been implicated in coronary artery disease, they do not add prognostic value over high-sensitivity CRP. Finally, aortic 18F-fluorodeoxyglucose positron emission tomography (PET) uptake, a robust marker of inflammation, has been used to demonstrate favorable association of biologic therapy with aortic 18F-fluorodeoxyglucose uptake.3
Elnabawi YA, Antoniades C, Mehta NN. Using Perivascular Fat Attenuation Index to Monitor Coronary Inflammation in Patients With Psoriasis—Reply. JAMA Cardiol. 2020;5(3):359–360. doi:10.1001/jamacardio.2019.5333
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