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January 15, 2020

Adverse Cardiovascular Outcomes for Women—Biology, Bias, or Both?

Author Affiliations
  • 1Emory University School of Medicine, Department Cardiology, Atlanta, Georgia
  • 2Emory Heart and Vascular Center, Atlanta, Georgia
  • 3Emory Women’s Heart Center, Atlanta, Georgia
JAMA Cardiol. 2020;5(3):253-254. doi:10.1001/jamacardio.2019.5576

In this issue of JAMA Cardiology, Ji et al1 identify that starting at an early age, women have steeper increases in blood pressure than men throughout life, setting the stage for cardiovascular disease presenting differently, not simply later, in women than men. This introduces the concept that biology serves as an underpinning of sex differences in the pathophysiology of cardiovascular illnesses, in subsequent distinct pathophysiologic alterations, and in the variability in treatment effectiveness. The authors view blood pressure as the single most accessible metric of vascular aging as well as the largest contributor to ischemic heart disease and heart failure risk in both sexes.

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