In this issue of JAMA Cardiology,1 an international research group reports results from the Incident Coronary Events Identified by Computed Tomography (ICONIC) Study, a prospective nested case-control study. Patients underwent coronary computed tomography angiography (CCTA) for suspected coronary artery disease (CAD). After a mean follow-up of 3.9 years, 189 patients were identified with acute coronary syndrome (ACS) and propensity-matched to 189 controls who remained ACS free. Importantly, the propensity matching included the qualitative coronary atherosclerotic extent based on CCTA. Overall, cases had less calcified coronary plaque and more fatty, fibrous, and necrotic core plaques. The most striking result was the greater number of high-attenuation plaques in controls, plaques with more than 1000 Hounsfield units that the authors termed 1K plaque.
Criqui MH, Forbang NI, Thomas IC. The Importance of Coronary Artery Calcium Density. JAMA Cardiol. 2020;5(3):290–291. doi:10.1001/jamacardio.2019.5745
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: