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Comment & Response
March 4, 2020

Improving Racial and Ethnic Minority Representation in Cardiovascular Disease Trials to Advance Health Equity—Reply

Author Affiliations
  • 1Faculty of Medical Science, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
  • 2ICES, Toronto, Ontario, Canada
  • 3Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  • 4Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
  • 5Cardiovascular Division, Women’s College Hospital, Toronto, Ontario, Canada
JAMA Cardiol. 2020;5(5):611-612. doi:10.1001/jamacardio.2020.0146

In Reply We appreciate Ifidon and colleagues’ letter regarding infrequent reporting of racial and ethnic minority groups among the included studies in our systematic review.1 The issue of racial disparities in the treatment of hypercholesterolemia has been well documented. Notably, rates of statin use are often lower in African American populations considered at highest risk of cardiovascular disease compared with white populations at equal risk.2 In secondary prevention, racial minority groups with coronary heart disease often have worse long-term cardiovascular outcomes and higher rates of mortality.3 Given these disparities, novel interventions that are effective among populations experiencing the greatest inequity in cardiovascular care—be they racial or ethnic minority groups, individuals with low socioeconomic status, women, or the intersection of multiple social categorizations—are critically important.4

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