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Comment & Response
September 30, 2020

Accuracy of New Equation to Calculate Low-Density Lipoprotein Cholesterol

Author Affiliations
  • 1Department of Pathology, University of Texas Southwestern Medical Center, Dallas
  • 2Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
JAMA Cardiol. 2021;6(1):121. doi:10.1001/jamacardio.2020.4408

To the Editor Sampson et al1 have suggested that their new equation is more accurate than all other currently available equations for the calculation of low-density lipoprotein cholesterol (LDL-C) levels and is ready for immediate implementation. For the derivation of the equation, they used LDL-C values from the β-quantification method generated over a period of 2 decades. In our opinion, the advantage of this equation is that it will reduce the number of samples reflexed to direct LDL-C measurement. Further, addressing the following points will improve the accuracy of the new equation.

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