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Comment & Response
September 30, 2020

Accuracy of New Equation to Calculate Low-Density Lipoprotein Cholesterol

Author Affiliations
  • 1Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 2Department of Cardiovascular Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar
JAMA Cardiol. 2021;6(1):121-122. doi:10.1001/jamacardio.2020.4411

To the Editor Sampson et al1 add welcome attention to low-density lipoprotein cholesterol (LDL-C) calculation accuracy. With our publications in 20132,3 and several subsequent publications,4,5 we hoped to inspire others to work on this clinically relevant issue. Not only do the authors further validate our LDL-C calculation, they propose a new equation (Equation 21) in reanalysis of National Institutes of Health data from the 1970s to the 1990s. However, Equation 2 appears to reintroduce known problems with LDL-C calculation.

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