Accuracy of New Equation to Calculate Low-Density Lipoprotein Cholesterol

Seth S. Martin; Mohamed B. Elshazly; Steven R. Jones

doi:10.1001/jamacardio.2020.4411

Comment & Response

September 30, 2020

Accuracy of New Equation to Calculate Low-Density Lipoprotein Cholesterol

Seth S. Martin, MD, MHS¹; Mohamed B. Elshazly, MD²; Steven R. Jones, MD¹

Author Affiliations Article Information

¹Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
²Department of Cardiovascular Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar

JAMA Cardiol. 2021;6(1):121-122. doi:10.1001/jamacardio.2020.4411

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To the Editor Sampson et al¹ add welcome attention to low-density lipoprotein cholesterol (LDL-C) calculation accuracy. With our publications in 2013²^,3 and several subsequent publications,⁴^,5 we hoped to inspire others to work on this clinically relevant issue. Not only do the authors further validate our LDL-C calculation, they propose a new equation (Equation 2¹) in reanalysis of National Institutes of Health data from the 1970s to the 1990s. However, Equation 2 appears to reintroduce known problems with LDL-C calculation.

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Accuracy of New Equation to Calculate Low-Density Lipoprotein Cholesterol

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Accuracy of New Equation to Calculate Low-Density Lipoprotein Cholesterol

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