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Comment & Response
March 31, 2021

An Excellent Model to Increase Adherence to Guideline-Directed Medical Therapy—With Far-reaching Implications—Reply

Author Affiliations
  • 1Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Cardiol. 2021;6(6):726-727. doi:10.1001/jamacardio.2021.0327

In Reply We appreciate the comments in support of our work1 by Karamat and colleagues and agree that the remote, algorithm-driven, navigator-led and pharmacist-led approach we used to optimize guideline-directed medical therapy for patients with heart failure and reduced ejection fraction can be readily adapted to implementation at scale or to management of other cardiovascular conditions. Indeed, additional work from our group has already highlighted that this strategy may be effective as a health care system–level intervention to improve control of lipids and blood pressure in accordance with guideline-recommended targets.2 Validation of these results in other clinical contexts along with longer-term follow-up to confirm the anticipated favorable effects on clinical outcomes and health care utilization may be needed to encourage broader adoption of this approach to cardiovascular risk reduction in clinical practice.

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