[Skip to Navigation]
Editor's Note
May 5, 2021

Genetic Studies of Atrial Fibrillation in Diverse Cohorts and Identification of Diverse Phenotypes Associated With Single Genes

Author Affiliations
  • 1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 2Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 3Web Editor, JAMA Cardiology
  • 4Center for Genetic Medicine, Bluhm Cardiovascular Institute, Northwestern University School of Medicine, Chicago, Illinois
  • 5Associate Editor for Translational Science, JAMA Cardiology
JAMA Cardiol. 2021;6(7):820. doi:10.1001/jamacardio.2021.1004

Premature truncations in the TTN gene, referred to as TTNtv, disrupt titin and are present in 15% to 20% of patients with dilated cardiomyopathy, where the disruptions have been most extensively studied. In addition, TTNtv are found in peripartum, chemotherapy-induced, and alcohol-associated cardiomyopathy, suggesting gene-environment interactions promote the onset of heart failure (HF). Atrial fibrillation (AF) and HF are interrelated; the presence of AF can trigger HF onset and vice versa, with newer data supporting shared genetic substrates for both AF and HF. Supporting this shared abnormality, TTNtv were recently identified in early-onset AF (occurring in individuals aged ≤66 years).1 This study examined AF in a European ancestry cohort in which AF is more common.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×