To the Editor We read with great interest the study conducted by Nestelberger et al1 bringing valuable information in a growing field of translational medicine. As stated by the authors, early discrimination of myocardial infarction (MI) type is of major importance and remains an everyday clinical challenge. They reported early biomarkers to provide modest discrimination in the early diagnosis of MI but stressed the importance of models combining clinical findings and selected biomarkers. We would like to address some comments related to the subject.