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September 2019 - April 2016

Decade

Year

Issue

September 2018, Vol 3, No. 9, Pages 787-898

In This Issue of JAMA Cardiology

Highlights

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):787. doi:10.1001/jamacardio.2017.3381
Original Investigation

Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):806-814. doi:10.1001/jamacardio.2018.2112

This randomized clinical trial explores the effect of infusions of the high-density lipoprotein mimetic MDCO-216 on reducing the burden of coronary atherosclerosis in statin-treated patients with acute coronary syndrome in Canada and Europe.

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):815-822. doi:10.1001/jamacardio.2018.2121

This randomized clinical trial determines the effect of an intravenous infusion of CER-001 on coronary atherosclerosis progression in statin-treated patients.

Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis

Abstract Full Text
free access has audio
JAMA Cardiol. 2018;3(9):823-828. doi:10.1001/jamacardio.2018.2258

This meta-analysis evaluates efficacy and safety of further lowering low-density lipoprotein cholesterol levels in patient populations presenting with median low-density lipoprotein cholesterol levels of 70 mg/dL or less.

Live-Born Major Congenital Heart Disease in Denmark: Incidence, Detection Rate, and Termination of Pregnancy Rate From 1996 to 2013

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):829-837. doi:10.1001/jamacardio.2018.2009

This population-based study evaluates time trends in incidence, detection rate, and termination of pregnancy rate of major congenital heart disease in fetuses in Denmark and assess the influence of the introduction of general prenatal screening in 2004.

Association of Left Ventricular Global Longitudinal Strain With Asymptomatic Severe Aortic Stenosis: Natural Course and Prognostic Value

Abstract Full Text
free access has audio
JAMA Cardiol. 2018;3(9):839-847. doi:10.1001/jamacardio.2018.2288

This registry-based study investigates the prevalence of impaired left venticular global longitudinal strain, its natural course, and its prognostic implications in Swedish patients with asymptomatic severe aortic stenosis with preserved left ventricular ejection fraction.

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):849-857. doi:10.1001/jamacardio.2018.2287

This phenome-wide association study assesses clinical associations between interleukin 6 receptor (IL6R) single-nucleotide polyporphisms and known IL6R drug effects and whether large biobanks and genetics can be used to assess potential beneficial and adverse effects of therapeutic agents with known pathways and related genes.

Brief Report

Pericoronary Adipose Tissue Computed Tomography Attenuation and High-Risk Plaque Characteristics in Acute Coronary Syndrome Compared With Stable Coronary Artery Disease

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):858-863. doi:10.1001/jamacardio.2018.1997

This case-control study explores the association of pericoronary adipose tissue computed tomography attenuation with culprit lesions compared with nonculprit lesions in patients with acute coronary syndrome and significantly stenosed lesions in stable controls with coronary artery disease.

Geographic Disparities in Reported US Amyloidosis Mortality From 1979 to 2015: Potential Underdetection of Cardiac Amyloidosis

Abstract Full Text
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JAMA Cardiol. 2018;3(9):865-870. doi:10.1001/jamacardio.2018.2093

This cohort study evaluates the temporal and regional trends in age-adjusted amyloidosis-related mortality among men and women of various races in the United States.

Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):871-876. doi:10.1001/jamacardio.2018.2371

This community-based cohort study measures the association of highly expressed circulating extracellular RNA molecules with incident heart failure and left ventricular remodeling.

Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women

Abstract Full Text
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JAMA Cardiol. 2018;3(9):877-882. doi:10.1001/jamacardio.2018.2251

This cohort study assesses the extent of sotalol-induced QT prolongation and specific T-wave changes after sotalol exposure in healthy nonmenopausal women according to the androgenic activity of the oral contraceptives they take.

Viewpoint

Defining the New Normal in Cardiovascular Risk Factors

Abstract Full Text
JAMA Cardiol. 2018;3(9):789-790. doi:10.1001/jamacardio.2018.1576

This Viewpoint offers a perspective on the use of the terms risk factor and normal in the context of cardiovascular health and disease.

The Limits and Hazards of Clinical Equipoise on Cardiology Study Design and Conduct

Abstract Full Text
JAMA Cardiol. 2018;3(9):791-792. doi:10.1001/jamacardio.2018.1691

This Viewpoint argues that clinical equipoise in studies of cardiology medications and procedures has drawbacks that militate against strict adherence.

Finding Means to Fulfill the Societal and Academic Imperative for Open Data Access and Sharing

Abstract Full Text
JAMA Cardiol. 2018;3(9):793-794. doi:10.1001/jamacardio.2018.0129

This Viewpoint describes ethical and practical challenges associated with scientific research data sharing and means to address them.

Moving From Hope to Hard Work in Data Sharing

Abstract Full Text
JAMA Cardiol. 2018;3(9):795-796. doi:10.1001/jamacardio.2018.0130

This Viewpoint discusses the benefits and drawbacks of public sharing of clinical trial data and prospective solutions for ethical concerns.

From the Heart

Living on a Wire

Abstract Full Text
JAMA Cardiol. 2018;3(9):804-805. doi:10.1001/jamacardio.2018.1332

This From the Heart describes a resident balancing his health issues with a pacemaker and clinical responsibilities.

Editorial

Data Sharing—The Time Has (Not Yet?) Come

Abstract Full Text
JAMA Cardiol. 2018;3(9):797-798. doi:10.1001/jamacardio.2018.1939

Apolipoprotein A-I Infusion Therapies for Coronary Disease: Two Outs in the Ninth Inning and Swinging for the Fences

Abstract Full Text
JAMA Cardiol. 2018;3(9):799-801. doi:10.1001/jamacardio.2018.2168

Low-Density Lipoprotein Cholesterol and Cardiovascular Risk Reduction: How Low Is Low Enough Without Causing Harm?

Abstract Full Text
has audio
JAMA Cardiol. 2018;3(9):802-803. doi:10.1001/jamacardio.2018.2273
Invited Commentary

Ethical Implications of Prenatal Screening for Congenital Heart Disease

Abstract Full Text
JAMA Cardiol. 2018;3(9):837-838. doi:10.1001/jamacardio.2018.1944

Moving Past Ejection Fraction in Timing of Aortic Stenosis Intervention

Abstract Full Text
has audio
JAMA Cardiol. 2018;3(9):847-848. doi:10.1001/jamacardio.2018.2451

Computed Tomographic Coronary Angiography Identification of Plaque Inflammation: An Imaging Target Within Reach?

Abstract Full Text
JAMA Cardiol. 2018;3(9):863-864. doi:10.1001/jamacardio.2018.2015
Review

Obesity-Associated Heart Failure as a Theoretical Target for Treatment With Mineralocorticoid Receptor Antagonists

Abstract Full Text
has active quiz
JAMA Cardiol. 2018;3(9):883-887. doi:10.1001/jamacardio.2018.2090

This narrative review highlights the association between abdominal obesity and circulating levels of aldosterone and advocates this association as a method of encouraging use of mineralocorticoid receptor antagonists in treating chronic heart failure.

JAMA Cardiology Clinical Challenge

Acute Coronary Syndrome in a 44-Year-Old Woman

Abstract Full Text
has active quiz
JAMA Cardiol. 2018;3(9):888-889. doi:10.1001/jamacardio.2018.0516

A 44-year-old African American woman without traditional atherosclerotic risk factors or known coronary artery disease presented to the emergency department with chest pain. Urgent coronary angiography revealed thrombolysis in myocardial infarction flow grade 2 in the left anterior descending artery and second diagonal branch. What would you do next?

Comment & Response

Coding Errors in Survey Study of Best Practices for In-Hospital Cardiac Arrest

Abstract Full Text
JAMA Cardiol. 2018;3(9):891-892. doi:10.1001/jamacardio.2018.2106

High-Sensitivity Troponin and Heart Failure With Preserved Ejection Fraction—Balancing P Values With Prior Knowledge and Common Sense

Abstract Full Text
JAMA Cardiol. 2018;3(9):892. doi:10.1001/jamacardio.2018.1620

High-Sensitivity Troponin and Heart Failure With Preserved Ejection Fraction—Balancing P Values With Prior Knowledge and Common Sense—Reply

Abstract Full Text
JAMA Cardiol. 2018;3(9):892-893. doi:10.1001/jamacardio.2018.1623

Different Population and End Point Definitions in Reproduction Analysis Based on Shared Data

Abstract Full Text
JAMA Cardiol. 2018;3(9):893-894. doi:10.1001/jamacardio.2018.1788

Different Population and End Point Definitions in Reproduction Analysis Based on Shared Data—Reply

Abstract Full Text
JAMA Cardiol. 2018;3(9):894. doi:10.1001/jamacardio.2018.1791

The Obesity Paradigm and Lifetime Risk of Cardiovascular Disease

Abstract Full Text
JAMA Cardiol. 2018;3(9):894-895. doi:10.1001/jamacardio.2018.1834

The Obesity Paradigm and Lifetime Risk of Cardiovascular Disease

Abstract Full Text
JAMA Cardiol. 2018;3(9):895-896. doi:10.1001/jamacardio.2018.1837

The Obesity Paradigm and Lifetime Risk of Cardiovascular Disease—Reply

Abstract Full Text
JAMA Cardiol. 2018;3(9):896-897. doi:10.1001/jamacardio.2018.1840

Randomized Clinical Trial Needed to Confirm Whether Dalcetrapib Improves Outcomes for Specific ADCY9 Genotype

Abstract Full Text
JAMA Cardiol. 2018;3(9):897. doi:10.1001/jamacardio.2018.2379

Randomized Trial Needed to Confirm Whether Dalcetrapib Improves Outcomes for Specific ADCY9 Genotype—Reply

Abstract Full Text
JAMA Cardiol. 2018;3(9):897-898. doi:10.1001/jamacardio.2018.2382
Correction

Error in Results and Figures 1, 2, and 3

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):898. doi:10.1001/jamacardio.2018.1681

Coding Errors in Survey Study

Abstract Full Text
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JAMA Cardiol. 2018;3(9):898. doi:10.1001/jamacardio.2018.2189

Error in Methods Section

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):898. doi:10.1001/jamacardio.2018.2503
JAMA Cardiology Masthead

JAMA Cardiology

Abstract Full Text
free access
JAMA Cardiol. 2018;3(9):788. doi:10.1001/jamacardio.2017.3382
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