This randomized clinical trial explores the effect of infusions of the high-density lipoprotein mimetic MDCO-216 on reducing the burden of coronary atherosclerosis in statin-treated patients with acute coronary syndrome in Canada and Europe.
This randomized clinical trial determines the effect of an intravenous infusion of CER-001 on coronary atherosclerosis progression in statin-treated patients.
This meta-analysis evaluates efficacy and safety of further lowering low-density lipoprotein cholesterol levels in patient populations presenting with median low-density lipoprotein cholesterol levels of 70 mg/dL or less.
This population-based study evaluates time trends in incidence, detection rate, and termination of pregnancy rate of major congenital heart disease in fetuses in Denmark and assess the influence of the introduction of general prenatal screening in 2004.
This registry-based study investigates the prevalence of impaired left venticular global longitudinal strain, its natural course, and its prognostic implications in Swedish patients with asymptomatic severe aortic stenosis with preserved left ventricular ejection fraction.
This phenome-wide association study assesses clinical associations between interleukin 6 receptor (IL6R) single-nucleotide polyporphisms and known IL6R drug effects and whether large biobanks and genetics can be used to assess potential beneficial and adverse effects of therapeutic agents with known pathways and related genes.
This case-control study explores the association of pericoronary adipose tissue computed tomography attenuation with culprit lesions compared with nonculprit lesions in patients with acute coronary syndrome and significantly stenosed lesions in stable controls with coronary artery disease.
This cohort study evaluates the temporal and regional trends in age-adjusted amyloidosis-related mortality among men and women of various races in the United States.
This community-based cohort study measures the association of highly expressed circulating extracellular RNA molecules with incident heart failure and left ventricular remodeling.
This cohort study assesses the extent of sotalol-induced QT prolongation and specific T-wave changes after sotalol exposure in healthy nonmenopausal women according to the androgenic activity of the oral contraceptives they take.
This Viewpoint offers a perspective on the use of the terms risk factor and normal in the context of cardiovascular health and disease.
This Viewpoint argues that clinical equipoise in studies of cardiology medications and procedures has drawbacks that militate against strict adherence.
This Viewpoint describes ethical and practical challenges associated with scientific research data sharing and means to address them.
This Viewpoint discusses the benefits and drawbacks of public sharing of clinical trial data and prospective solutions for ethical concerns.
This From the Heart describes a resident balancing his health issues with a pacemaker and clinical responsibilities.
This narrative review highlights the association between abdominal obesity and circulating levels of aldosterone and advocates this association as a method of encouraging use of mineralocorticoid receptor antagonists in treating chronic heart failure.
A 44-year-old African American woman without traditional atherosclerotic risk factors or known coronary artery disease presented to the emergency department with chest pain. Urgent coronary angiography revealed thrombolysis in myocardial infarction flow grade 2 in the left anterior descending artery and second diagonal branch. What would you do next?
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