July 2020, Vol 5, No. 7, Pages 741-848

Original Investigation

Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial

Mona Fiuzat, PharmD; Justin Ezekowitz, MB BCh, MSc; Wendimagegn Alemayehu, PhD; et al.

Abstract Full Text

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JAMA Cardiol. 2020;5(7):757-764. doi:10.1001/jamacardio.2020.0640

This secondary analysis of a randomized clinical trial examines medical therapy and reasons why an intervention did not work for patients with heart failure in the Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment.

Performance of Hospitals When Assessing Disease-Based Mortality Compared With Procedural Mortality for Patients With Acute Myocardial Infarction

Ashwin S. Nathan, MD; Qun Xiang, MS; Daniel Wojdyla, MS; et al.

Abstract Full Text

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JAMA Cardiol. 2020;5(7):765-772. doi:10.1001/jamacardio.2020.0753

This cross-sectional study examines correlation and reclassification between hospital-level disease-specific mortality and percutaneous coronary intervention procedural mortality among patients with acute myocardial infarction.

Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia: Secondary Analysis of the ISCHEMIA Randomized Clinical Trial

Harmony R. Reynolds, MD; Leslee J. Shaw, PhD; James K. Min, MD; et al.

Abstract Full Text

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JAMA Cardiol. 2020;5(7):773-786. doi:10.1001/jamacardio.2020.0822

This secondary analysis of the ISCHEMIA randomized clinical trial describes sex differences in stress testing, coronary computed tomographic angiography findings, and symptoms in patients with stable ischemic heart disease.

Editorial
Sex Differences in Ischemic Heart Disease—the Paradox Persists
Rodrigo Mendirichaga, MD; Alice K. Jacobs, MD

Effect of Evolocumab on Type and Size of Subsequent Myocardial Infarction: A Prespecified Analysis of the FOURIER Randomized Clinical Trial

Stephen D. Wiviott, MD; Robert P. Giugliano, MD, SM; David A. Morrow, MD, MPH; et al.

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JAMA Cardiol. 2020;5(7):787-793. doi:10.1001/jamacardio.2020.0764

This prespecified analysis of a randomized clinical trial evaluates the effect of evolocumab on type and size of subsequent myocardial infarction.

Invited Commentary
Toward a More Detailed Reporting of MI Reduction in Clinical Trials—A Welcome and Needed Step in the Right Direction
Glenn N. Levine, MD

Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life

Chike C. Nwabuo, MD, MPH; Yuichiro Yano, MD, PhD; Henrique T. Moreira, MD, PhD; et al.

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JAMA Cardiol. 2020;5(7):795-801. doi:10.1001/jamacardio.2020.0799

This cohort study examines the association between blood pressure variability in early adulthood and myocardial structure and function in middle age.

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Shaobo Shi, MD; Mu Qin, MD; Bo Shen, MD; et al.

Abstract Full Text

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JAMA Cardiol. 2020;5(7):802-810. doi:10.1001/jamacardio.2020.0950

This cohort study, conducted from January 20, 2020, to February 10, 2020, in Wuhan, China, explores the prevalence of cardiac injury in hospitalized patients with COVID-19 and its association with mortality.

Editorial
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality
Robert O. Bonow, MD, MS; Gregg C. Fonarow, MD; Patrick T. O’Gara, MD; Clyde W. Yancy, MD, MSc
- Audio Author Interview: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Tao Guo, MD; Yongzhen Fan, MD; Ming Chen, MD; et al.

Abstract Full Text

open access

JAMA Cardiol. 2020;5(7):811-818. doi:10.1001/jamacardio.2020.1017

This case series study evaluates the association of underlying cardiovascular disease and myocardial injury on fatal outcomes in patients with coronavirus disease 2019 (COVID-19).

Editorial
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality
Robert O. Bonow, MD, MS; Gregg C. Fonarow, MD; Patrick T. O’Gara, MD; Clyde W. Yancy, MD, MSc
- Audio Author Interview: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Brief Report

Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)

Riccardo M. Inciardi, MD; Laura Lupi, MD; Gregorio Zaccone, MD; et al.

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JAMA Cardiol. 2020;5(7):819-824. doi:10.1001/jamacardio.2020.1096

This case report describes the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms.

Editorial
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality
Robert O. Bonow, MD, MS; Gregg C. Fonarow, MD; Patrick T. O’Gara, MD; Clyde W. Yancy, MD, MSc
- Audio Author Interview: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China

Juyi Li, MD; Xiufang Wang, MS; Jian Chen, BS; et al.

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JAMA Cardiol. 2020;5(7):825-830. doi:10.1001/jamacardio.2020.1624

This cohort study examines the association between angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and severity of illness and mortality in patients with hypertension hospitalized for COVID-19 infection.

Research Letter

Digital Informed Consent in a Rural and Low-Income Population

Donald Clark III, MD, MPH; Julia Woods, PharmD; Deepti Patki, MS; et al.

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JAMA Cardiol. 2020;5(7):845-847. doi:10.1001/jamacardio.2020.0984

This cohort study examines a process of digitized informed consent for the enrollment of a rural population in research.

Viewpoint

An Acute Respiratory Infection Runs Into the Most Common Noncommunicable Epidemic—COVID-19 and Cardiovascular Diseases

Chengzhi Yang, MD, PhD; Zening Jin, MD, PhD

Abstract Full Text

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JAMA Cardiol. 2020;5(7):743-744. doi:10.1001/jamacardio.2020.0934

This Viewpoint discusses the evidence of pathophysiological and epidemiological connections between COVID-19 and cardiovascular diseases and treatments.

Editorial
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality
Robert O. Bonow, MD, MS; Gregg C. Fonarow, MD; Patrick T. O’Gara, MD; Clyde W. Yancy, MD, MSc
- Audio Author Interview: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers

Chirag Bavishi, MD, MPH; Thomas M. Maddox, MD, MSc; Franz H. Messerli, MD

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JAMA Cardiol. 2020;5(7):745-747. doi:10.1001/jamacardio.2020.1282

This Viewpoint discusses recommendations for angiotensin-converting enzyme inhibitor and angiotensin receptor blocker use in patients with or at risk of contracting coronavirus disease 2019 (COVID-19).

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science

Majd AlGhatrif, MD, MA; Oscar Cingolani, MD; Edward G. Lakatta, MD

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JAMA Cardiol. 2020;5(7):747-748. doi:10.1001/jamacardio.2020.1329

This Viewpoint discusses whether individuals should continue to take angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the context of coronavirus disease 2019 (COVID-19).

From the Heart

Fellowship in the Time of Coronavirus Disease 2019 (COVID-19): A Time to Adapt

Katherine H. Chau, MD; Shayan Nabavi Nouri, MD; Mahesh V. Madhavan, MD

Abstract Full Text

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JAMA Cardiol. 2020;5(7):749-750. doi:10.1001/jamacardio.2020.1562

This essay describes how the authors’ fellowship training has changed because of the coronavirus disease 2019 (COVID-19) pandemic.

Editorial

Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Robert O. Bonow, MD, MS; Gregg C. Fonarow, MD; Patrick T. O’Gara, MD; et al.

Abstract Full Text

free access has audio

JAMA Cardiol. 2020;5(7):751-753. doi:10.1001/jamacardio.2020.1105

Audio Author Interview: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Sex Differences in Ischemic Heart Disease—the Paradox Persists

Rodrigo Mendirichaga, MD; Alice K. Jacobs, MD

Abstract Full Text

JAMA Cardiol. 2020;5(7):754-756. doi:10.1001/jamacardio.2020.0819

Invited Commentary

Toward a More Detailed Reporting of MI Reduction in Clinical Trials—A Welcome and Needed Step in the Right Direction

Glenn N. Levine, MD

Abstract Full Text

JAMA Cardiol. 2020;5(7):793-794. doi:10.1001/jamacardio.2020.0749

Review

Potential Effects of Coronaviruses on the Cardiovascular System: A Review

Mohammad Madjid, MD, MS; Payam Safavi-Naeini, MD; Scott D. Solomon, MD; et al.

Abstract Full Text

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JAMA Cardiol. 2020;5(7):831-840. doi:10.1001/jamacardio.2020.1286

This narrative review provides an overview of the basics of coronaviruses, with a focus on coronavirus disease 2019 along with their effects on the cardiovascular system.

Editorial
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality
Robert O. Bonow, MD, MS; Gregg C. Fonarow, MD; Patrick T. O’Gara, MD; Clyde W. Yancy, MD, MSc
- Audio Author Interview: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

JAMA Cardiology Clinical Challenge

An Unusual Electrocardiogram Following Pacemaker Implantation

Jacob J. Mayfield, MD; Nora Goldschlager, MD

Abstract Full Text

JAMA Cardiol. 2020;5(7):843-844. doi:10.1001/jamacardio.2020.1061

A man in his 30s presented for follow-up of a newly installed pacemaker, and electrocardiography resulted in an unusual image. What would you do next?

Cardiovascular Images

A Man in His 20s With New-Onset Severe Heart Failure and Ventricular Tachycardia

Haider J Warraich, MD; David Manly, MD

Abstract Full Text

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JAMA Cardiol. 2020;5(7):841. doi:10.1001/jamacardio.2020.1054

This case report describes a man in his 20s with severe heart failure, ventricular arrhythmias, and unrevealing biopsy.

A Woman in Her 50s With Dyspnea, Palpitation, and Severely Elevated Pulmonary Artery Pressure

Yuk Ming Lau, MBBS; Hung Fat Tse, MD, PhD

Abstract Full Text

JAMA Cardiol. 2020;5(7):842. doi:10.1001/jamacardio.2020.1048

This case report describes a left atrial mass suspected to be an intracardiac thrombus.

Comment & Response

Initial Monthly Cost of Tafamidis—the Real Price for Patients

Sarah A. M. Cuddy, MBChB; Melissa L. Coyle, PharmD, CSP; Rodney H. Falk, MD

Abstract Full Text

JAMA Cardiol. 2020;5(7):847-848. doi:10.1001/jamacardio.2020.0863

Initial Monthly Cost of Tafamidis—the Real Price for Patients—Reply

Jerry H. Gurwitz, MD; Mathew S. Maurer, MD

Abstract Full Text

JAMA Cardiol. 2020;5(7):848. doi:10.1001/jamacardio.2020.0866

Correction

Error in Text

Abstract Full Text

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JAMA Cardiol. 2020;5(7):848. doi:10.1001/jamacardio.2020.1722

April 2023 - April 2016

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July 2020, Vol 5, No. 7, Pages 741-848

Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial

Performance of Hospitals When Assessing Disease-Based Mortality Compared With Procedural Mortality for Patients With Acute Myocardial Infarction

Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia: Secondary Analysis of the ISCHEMIA Randomized Clinical Trial

Effect of Evolocumab on Type and Size of Subsequent Myocardial Infarction: A Prespecified Analysis of the FOURIER Randomized Clinical Trial

Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China

Digital Informed Consent in a Rural and Low-Income Population

An Acute Respiratory Infection Runs Into the Most Common Noncommunicable Epidemic—COVID-19 and Cardiovascular Diseases

Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science

Fellowship in the Time of Coronavirus Disease 2019 (COVID-19): A Time to Adapt

Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

Sex Differences in Ischemic Heart Disease—the Paradox Persists

Toward a More Detailed Reporting of MI Reduction in Clinical Trials—A Welcome and Needed Step in the Right Direction

Potential Effects of Coronaviruses on the Cardiovascular System: A Review

An Unusual Electrocardiogram Following Pacemaker Implantation

A Man in His 20s With New-Onset Severe Heart Failure and Ventricular Tachycardia

A Woman in Her 50s With Dyspnea, Palpitation, and Severely Elevated Pulmonary Artery Pressure

Initial Monthly Cost of Tafamidis—the Real Price for Patients

Initial Monthly Cost of Tafamidis—the Real Price for Patients—Reply

Error in Text

JAMA Cardiology

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