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September 15, 2021
Original Investigation

Potential Implications of Expanded US Food and Drug Administration Labeling for Sacubitril/Valsartan in the US

Abstract Full Text
JAMA Cardiol. Published online September 15, 2021. doi:10.1001/jamacardio.2021.3651

This decision analytical model study quantifies newly eligible treatment candidates for sacubitril/valsartan under the expanded US Food and Drug Administration labeling and uses data from the PARAGON-HF trial to evaluate treatment effects and the number needed to treat to prevent 1 worsening HF event.

Brief Report

Association of Myocardial Blood Flow Reserve With Adverse Left Ventricular Remodeling in Patients With Aortic Stenosis: The Microvascular Disease in Aortic Stenosis (MIDAS) Study

Abstract Full Text
has audio
JAMA Cardiol. Published online September 15, 2021. doi:10.1001/jamacardio.2021.3396

This observational study investigates whether myocardial flow reserve and stress myocardial blood flow are associated with left ventricular structure and function derangements, and whether these parameters improve after aortic valve replacement.

Research Letter

Premature Menopause and 10-Year Risk Prediction of Atherosclerotic Cardiovascular Disease

Abstract Full Text
JAMA Cardiol. Published online September 15, 2021. doi:10.1001/jamacardio.2021.3490

This cohort study assesses whether adding premature menopause status to pooled cohort equations improves risk prediction of atherosclerotic cardiovascular disease among women.

Editorial

An Expanded Heart Failure Indication for Sacubitril/Valsartan: Evolving the Evidence Bar

Abstract Full Text
JAMA Cardiol. Published online September 15, 2021. doi:10.1001/jamacardio.2021.3658
September 8, 2021
Original Investigation

Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes

Abstract Full Text
open access
JAMA Cardiol. Published online September 8, 2021. doi:10.1001/jamacardio.2021.3370

This cohort study of individuals with early-onset atrial fibrillation examines the prevalence of disease-associated variants in susceptibility genes for inherited cardiomyopathy and arrhythmia syndromes.

Gender Differences in Medicare Payments Among Cardiologists

Abstract Full Text
JAMA Cardiol. Published online September 8, 2021. doi:10.1001/jamacardio.2021.3385

This cross-sectional study determines whether gender differences exist in the reimbursements, charges, and reimbursement per charge from the Centers for Medicare & Medicaid Services.

Viewpoint

Implications of Premature Coronary Artery Calcification in Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease

Abstract Full Text
JAMA Cardiol. Published online September 8, 2021. doi:10.1001/jamacardio.2021.3393

This Viewpoint discusses the potential value of incidentally observed coronary artery calcification (CAC) in deciding to initiate early prevention, even in the absence of symptoms.

Editorial

Early-Onset Atrial Fibrillation and Heritable Heart Disease—To Test or Not to Test?

Abstract Full Text
JAMA Cardiol. Published online September 8, 2021. doi:10.1001/jamacardio.2021.3367
Correction

Change to Open Access Status

Abstract Full Text
free access
JAMA Cardiol. Published online September 8, 2021. doi:10.1001/jamacardio.2021.3756
September 1, 2021
Original Investigation

Effect of Goal-Setting Approaches Within a Gamification Intervention to Increase Physical Activity Among Economically Disadvantaged Adults at Elevated Risk for Major Adverse Cardiovascular Events: The ENGAGE Randomized Clinical Trial

Abstract Full Text
JAMA Cardiol. Published online September 1, 2021. doi:10.1001/jamacardio.2021.3176

This randomized clinical trial examines the use of differing methods of goal setting and implementation in gamification of individuals at risk for major cardiovascular events.

Associations of High-Sensitivity Troponin and Natriuretic Peptide Levels With Outcomes After Intensive Blood Pressure Lowering: Findings From the SPRINT Randomized Clinical Trial

Abstract Full Text
JAMA Cardiol. Published online September 1, 2021. doi:10.1001/jamacardio.2021.3187

This post hoc analysis of SPRINT examines whether elevated high-sensitivity cardiac troponin T and N-terminal pro–B-type natriuretic peptide levels can identify individuals with the greatest risk for mortality and heart failure and the largest benefit from intensive systolic blood pressure lowering.

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