Since the 1970s, the prevalence of antibiotic-resistant strains of Propionibacteriums acnes has increased. There are public health concerns about the development of antibiotic resistance among pathogenic organisms, including Staphyloccocusaureus. Furthermore, with the use of tetracyclines in the treatment of methacillin-resistant S aureus, concern has been raised regarding the potential contribution of bacterial resistance resulting from the widespread use of tetracyclines in the treatment of skin diseases such as acne.1