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Aug 2011

S-100 –Negative, CD1a-Positive Histiocytosis: A New Variant With Features of Both Indeterminate Cells and Interstitial Dermal Dendrocytes

Author Affiliations

Author Affiliations: Division of Dermatopathology, Mount Sinai School of Medicine, New York, New York.

Arch Dermatol. 2011;147(8):995-997. doi:10.1001/archdermatol.2011.219

The histiocytoses are a group of rare diseases that represent a proliferation of dendritic cells or macrophages. We describe a patient who presented with a cutaneous-limited histiocytosis with histologic features of indeterminate cell histiocytosis that uniquely failed to express S-100.

A 79-year-old white man presented with multiple erythematous nonpruritic papules on his chest, abdomen, upper arms, and back (Figure 1). The eruption, present for approximately 6 months, had failed to respond to high-dose steroids prescribed by a previous dermatologist. Our initial impression was of a contact dermatitis or other eczematous reaction.

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