Dramatic Improvement of Facial Angiofibromas in Tuberous Sclerosis With Topical Rapamycin: Optimizing a Treatment Protocol

In a recent report on the use of topical rapamycin to treat facial angiofibromas, Haemel et al¹ demonstrated the efficacy of rapamycin tablets mixed in petrolatum, 1%, ointment. Based on these findings and another report of topical rapamycin solution compounded with Eucerin (Eucerin, Hamburg, Germany),² we proceeded with a similar approach in our patient with tuberous sclerosis complex (TSC).