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Oct 2011

Treatment of Refractory Tumor Necrosis Factor Inhibitor –Induced Palmoplantar Pustulosis: A Report of 2 Cases

Author Affiliations

Author Affiliations: Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.

Arch Dermatol. 2011;147(10):1228-1230. doi:10.1001/archdermatol.2011.275

Tumor necrosis factor (TNF) inhibitor –induced palmoplantar pustulosis (PPP) is an uncommon cutaneous eruption characterized by sterile pustules on the palms and soles, along with hyperkeratosis, erythema, scaling, and fissuring. While some cases can be treated conservatively, a subset of patients present with severe, refractory disease, even after discontinuation of the inciting medication and the addition of systemic biologic agents, resulting in a considerable detriment to their quality of life. We report 2 such cases and our unique treatment approach.

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