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Oct 2011

Double Screening for Latent Tuberculosis Infection in Patients Treated With Anti –Tumor Necrosis Factor α

Author Affiliations

Author Affiliations: Departments of Dermatology (Drs Sempau, Gonz ález-Sixto, S ánchez-Sambucetty, P érez-Bustillo, and Rodr íguez-Prieto) and Immunology (Dr Ruiz de Morales), Complejo Asistencial Universitario de Le ón, Le ón, Spain.

Arch Dermatol. 2011;147(10):1233-1234. doi:10.1001/archdermatol.2011.270

The use of drugs that block the action of tumor necrosis factor α increases the risk of reactivation of latent tuberculosis infection (LTI).1 Screening before beginning treatment reduces the number of cases of tuberculosis by up to 78% to 85%.2

We describe 3 patients who were treated with anti –tumor necrosis factor α and in whom a combined tuberculin test (TT) and interferon gamma release assay (IGRA) (QuantiFERON-TB Gold; Cellestis Inc, Valencia, California) allowed the diagnosis of a recent contact or an LTI that would have not been detected with a TT alone (Table).