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Oct 2011

Erythematous Patches and Plaques on the Chest With Induration of the Breasts —Diagnosis

Author Affiliations
 

SECTION EDITOR: MARY S. STONE, MD; ASSISTANT SECTION EDITORS: SOON BAHRAMI, MD; CARRIE ANN R. CUSACK, MD; SENAIT W. DYSON, MD; MOLLY A. HINSHAW, MD; ARNI K. KRISTJANSSON, MD

Arch Dermatol. 2011;147(10):1215-1220. doi:10.1001/archdermatol.2011.284-b

Clusters of tumor cells are seen in the dermis and dermal lymphatics, which display a large epithelioid cell appearance with abundant cytoplasm, form papillary clusters, and are associated with inflammatory cells (Figure 3). The tumor cells are positive for cytokeratin 7 and focally for cluster of differentiation 10, but negative for thyroid transcription factor 1 and thyroglobulin, and are identified in dermal lymphatics, compatible with metastatic papillary RCC. The tumor cells are immunoreactive for PAX8, further supporting a renal cell origin. The patient was treated with hydrocortisone valerate, 0.2%, and emollients for symptomatic relief of pruritus, and treatment with temsirolimus was continued. The patient died 2 months after the presentation.

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