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Nov 2011

Rapid Cutaneous Dissemination of Persistently Agminated Lymphomatoid Papulosis in a 9-Year-Old Boy

Author Affiliations

Author Affiliations: Department of Dermatology, University Hospitals Case Medical Center/Case Western Reserve University, and Multidisciplinary Cutaneous Oncology Program, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio (Drs Chan and Tamburro); Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland (Drs Chan, Tamburro, and Mostow); Department of Dermatology, Northeast Ohio Medical University, Rootstown (Mr Staidle and Dr Mostow); Department of Dermatology, University Hospitals Richmond Medical Center, Richmond Heights, Ohio (Dr Tamburro); and Akron Dermatology, Akron, Ohio (Dr Mostow).

Arch Dermatol. 2011;147(11):1340-1342. doi:10.1001/archdermatol.2011.348

Although “localized ” or “regional ” eruptions of lymphomatoid papulosis (LyP) have been reported in the literature, specific references to distinct grouped lesions in a circumscribed patch have been reported in the context of persistent agminated lymphomatoid papulosis (PALP).1-4 It has been suggested that an “agminated CD30+ lymphoproliferative disorder  .  .  .  be considered a lymphoma, ”1(p1011) owing in part to the potential for disease progression to mycosis fungoides –like patches if untreated, and that PALP be treated aggressively with ablation therapy, specifically radiation therapy.1 Of the 9 reported cases of PALP that we found in the literature,1-4 only 1 case, in a 27-year-old man, evolved to disseminated classic LyP.2 We report herein a case of steroid-responsive agminated LyP in a pediatric patient that quickly evolved to disseminated disease, thus providing further evidence to support aggressive treatment of agminated LyP.

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