Author Affiliations: Department of Dermatology, University Hospitals Case Medical Center/Case Western Reserve University, and Multidisciplinary Cutaneous Oncology Program, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio (Drs Chan and Tamburro); Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland (Drs Chan, Tamburro, and Mostow); Department of Dermatology, Northeast Ohio Medical University, Rootstown (Mr Staidle and Dr Mostow); Department of Dermatology, University Hospitals Richmond Medical Center, Richmond Heights, Ohio (Dr Tamburro); and Akron Dermatology, Akron, Ohio (Dr Mostow).
Although “localized ” or “regional ” eruptions of lymphomatoid papulosis (LyP) have been reported in the literature, specific references to distinct grouped lesions in a circumscribed patch have been reported in the context of persistent agminated lymphomatoid papulosis (PALP).1-4 It has been suggested that an “agminated CD30+ lymphoproliferative disorder . . . be considered a lymphoma, ”1(p1011) owing in part to the potential for disease progression to mycosis fungoides –like patches if untreated, and that PALP be treated aggressively with ablation therapy, specifically radiation therapy.1 Of the 9 reported cases of PALP that we found in the literature,1-4 only 1 case, in a 27-year-old man, evolved to disseminated classic LyP.2 We report herein a case of steroid-responsive agminated LyP in a pediatric patient that quickly evolved to disseminated disease, thus providing further evidence to support aggressive treatment of agminated LyP.
Chan DV, Staidle J, Tamburro J, Mostow E. Rapid Cutaneous Dissemination of Persistently Agminated Lymphomatoid Papulosis in a 9-Year-Old Boy. Arch Dermatol. 2011;147(11):1340–1342. doi:10.1001/archdermatol.2011.348
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