[Skip to Navigation]
Nov 2011

Sweat the Small Stuff: The Importance of Clinical-Pathologic Correlation in Cutaneous GVHD Following Orthotopic Liver Transplant

Author Affiliations

Author Affiliations: DermSurgery Associates, Houston, Texas (Drs Moody, Kazakevich, Smith, Holzer, and Goldberg and Ms Landau); Department of Dermatology, Weill Cornell Medical College, Methodist Hospital, Houston (Drs Kazakevich, Smith, Holzer, and Goldberg); St Joseph Dermatology, Houston (Dr Tschen); and Department of Dermatology, University of Texas, Houston (Dr Goldberg).

Arch Dermatol. 2011;147(11):1345-1346. doi:10.1001/archdermatol.2011.331

Graft vs host disease (GVHD) is an immunologically mediated disorder. Donor lymphocytes (T cells) from transplanted tissues attack major histocompatibility complex (MHC) antigens on cells of the immunosuppressed recipient.1 Classic targets are rapidly dividing cells of the liver, gastrointestinal tract, skin and bone marrow, giving rise to clinical manifestations of jaundice, diarrhea, dermatitis, and pancytopenia.