Mr Sherlock Holmes was measuring the white spots dotting the body of the dark-haired, middle-aged man seated before us. The Royal Medical Society had asked Holmes to diagnose this puzzling skin malady. Holmes announced, “Watson, this is most interesting. All the lesions measure exactly ¾ inch square, roughly the size of a large bean. Each spot has 2 white hairs within it. ”
I wasn't sure where Holmes was going with this. To me, the diagnosis was vitiligo of 7 days' duration. I glanced at Holmes. Despite the passage of time, Holmes was still sharp of mind and could solve any crime or challenge placed before him.
Hoenig LJ. Sherlock Holmes and the Mysterious White Spots. Arch Dermatol. 2011;147(11):1305. doi:10.1001/archdermatol.2011.288
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.