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Jan 2012

Atypical Gingivitis Heralding a Case of Orofacial Granulomatosis

Author Affiliations

Author Affiliations: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Arch Dermatol. 2012;148(1):139-140. doi:10.1001/archdermatol.2011.992

Orofacial granulomatosis is a disorder of the orofacial soft tissues characterized clinically by recurrent to persistent lip and facial swelling and histopathologically by noncaseating granulomatous inflammation, lymphangiectasia, and perivascular lymphocytic inflammation.1,2 It is a diagnosis of exclusion considered to represent a spectrum of clinical entities including cheilitis granulomatosa and Melkersson-Rosenthal syndrome. We describe herein a case of granulomatous stomatitis presenting with atypical gingivitis consistent with orofacial granulomatosis. Since granulomatous stomatitis may be a marker for systemic disease, it is imperative to rule out other potentially associated conditions.

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