Since 2000, there has been a steady increase in the incidence of syphilis in the United States.1 In 2009, 13 997 cases of primary and secondary syphilis were reported, with an incidence rate of 4.6 cases per 100 000 persons.1 In light of this epidemic, the highly treatable nature of the disease, and the potential for serious sequelae if it is left untreated, recognition of the varied cutaneous manifestations of syphilis is critical. A case of secondary syphilis presenting with lesions of panniculitis on the legs is herein described.