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Correspondence
April 1962

QUESTIONS ON THE BIOCHEMICAL GENESIS OF ACANTHOLYSIS

Author Affiliations

University Hospitals of Cleveland University Circle Cleveland 6

Arch Dermatol. 1962;85(4):543-544. doi:10.1001/archderm.1962.01590040107028

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Abstract

To the Editor:  I read the article "Observations on the Biochemical Genesis of Acantholysis," Archives of Dermatology 84:459, 1961.As is always true when investigators work on similar problems, there are questions that arise, both in methodology and interpretation.

  1. They did not observe inhibition of acantholysis with intraepidermal injections of HgCl2 and CuCl2. In our work, acantholysis was inhibited by injections of Hg++ which were intradermal, of higher concentration than the authors', and the incubations were carried out in a moist atmosphere rather than in a solution where the concentration of the injected HgCl2 would be greatly decreased by diffusion into the surrounding media.

  1. They state (p. 462) that BAL does not produce the histologic changes caused by cantharidin. Perhaps my confusion over this paragraph is due to lack of detail regarding their work in this area. However, how does this suggest that cantharidin acantholysis is not

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