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June 2012

Complete Clearance of Reticular Erythematous Mucinosis With Quinacrine Monotherapy

Author Affiliations

Author Affiliations: Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany.

Arch Dermatol. 2012;148(6):768-769. doi:10.1001/archdermatol.2012.53

Reticular erythematous mucinosis (REM) syndrome is a rare skin disease that predominantly affects the chest area of middle-aged women.1 The clinical and histopathologic features of REM syndrome suggest a close association with cutaneous lupus erythematosus (CLE). Antimalarial drugs are the first-line systemic treatment for CLE, and many patients with REM also show improvement or clearing of their skin lesions after treatment with antimalarial agents.1,2 However, in a small proportion of patients, conventional antimalarial agents such as chloroquine or hydroxychloroquine might be unsuitable, for example in patients with certain eye diseases. We herein report a case of REM syndrome with a contraindication for conventional antimalarial agents that completely cleared with quinacrine hydrochloride monotherapy.

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