In this issue, Wu et al1 report a 79.3% prevalence of dyslipidemia (DLP) among adults with granuloma annulare (GA) compared with a 51.9% prevalence of DLP in controls matched for age, sex, race/ethnicity, and presence of type 2 diabetes mellitus, hypothyroidism, and hypertension (P < .001). Although the cause of GA is unknown,2 the finding of DLP among so many patients comes as a surprise. Heretofore, only vague hints suggested a possible association with a lipid abnormality. Patients with generalized GA occasionally have an abnormality of glucose metabolism, microangiopathy, and microdroplet lipid deposits inside histiocytes.
Dahl MV. Testing Lipid Levels in Granuloma Annulare: Comment on “Dyslipidemia in Granuloma Annulare”. Arch Dermatol. 2012;148(10):1136–1137. doi:10.1001/archdermatol.2012.1503
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