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Evidence-Based Dermatology: Research Commentary
Aug 2012

The Relationship Between Hygiene and Microbial Burden in Atopic Dermatitis Risk Based on a Systematic Review

Author Affiliations
 

SECTION EDITOR: MICHAEL BIGBY, MD; ASSISTANT SECTION EDITORS: OLIVIER CHOSIDOW, MD, PhD; ROBERT P. DELLAVALLE, MD, PhD, MSPH; DAIHUNG DO, MD; URBÀ GONZÁLEZ, MD, PhD; CATALIN M. POPESCU, MD, PhD; HYWEL WILLIAMS, MSc, PhD, FRCP

Arch Dermatol. 2012;148(8):936-938. doi:10.1001/archdermatol.2012.1410

Commentary on: Atopic dermatitis and the hygiene hypothesis revisitedFlohr C, Yeo L Curr Probl Dermatol. 2011;41:1-34

Question: Is there evidence to support an association between atopic dermatitis (AD) and hygiene as it relates to microbial burden? Does the literature support a link between any particular infectious or anti-infectious (ie, antibiotics, vaccinations) agent and AD?

Data Sources: A systematic review of the literature was performed using studies identified via a MEDLINE search from 1966 until June 2010. Search findings were supplemented by a hand search of references contained within studies located by MEDLINE search. 49 new studies were deemed suitable for inclusion.

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