Acrodermatitis enteropathica is a periorificial and intertriginous papulosquamous eruption typically seen in infants with hereditary intestinal zinc-transporter defects.1 However, acquired acrodermatitis enteropathica (AAE) can occur when serum zinc levels are depressed. Herein, we report 4 cases of AAE in elderly patients. Patients presented with refractory periorificial and intertriginous eruptions that were attributable to acquired zinc deficiency from poor diet and use of common medications.