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Aug 2012

Unusual Complication of Vemurafenib Treatment of Metastatic Melanoma: Exacerbation of Acantholytic Dyskeratosis Complicated by Kaposi Varicelliform Eruption

Author Affiliations

Author Affiliations: Divisions of Dermatology (Dr Gupta, Huang, and Cornelius) and Medical Oncology (Dr Linette), Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri.

Arch Dermatol. 2012;148(8):966-968. doi:10.1001/archdermatol.2012.758

Treatment with vemurafenib, a small-molecule BRAF inhibitor, has led to dramatic regression of metastatic melanomas harboring a V600E BRAF mutation. As with other kinase inhibitors, the use of vemurafenib has been accompanied by several dermatologic adverse effects. We describe a patient who experienced exacerbation of preexisting acantholytic dyskeratosis in a dose-dependent manner shortly after starting vemurafenib treatment. This was subsequently complicated by Kaposi varicelliform eruption and cessation of the drug treatment owing to progression of the disease.

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