Author Affiliations: Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Adult-onset xanthogranuloma (AOX) is a rare, benign, xanthogranulomatous condition that occurs equally among men and women throughout adulthood. The cause and incidence of AOX are unknown. Since 1963, when AOX was first described,1 a few hundred cases have been reported. The disease presents as yellowish-brown skin tumors of varying size that are usually solitary but can be multiple and occur most frequently on the head and neck. Adult-onset xanthogranuloma is without systemic findings. Clinical manifestations of adult xanthogranulomatous diseases occur in several forms, with or without systemic involvement, and are divided into 4 clinical subtypes: AOX, necrobiotic xanthogranuloma, adult periocular xanthogranuloma associated with asthma, and adult-onset xanthogranuloma associated with Erdheim-Chester disease.2,3
Halkjær LB, Wulf HC. X-ray Therapy of Adult-Onset Xanthogranuloma Ulcerating Tumors in a 79-Year-Old Man: Report of a Case and Comment. Arch Dermatol. 2012;148(8):968–969. doi:10.1001/archdermatol.2012.193