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Sep 2012

Antimalarial Myopathy in Amyopathic Dermatomyositis

Author Affiliations

Author Affiliations: Departments of Dermatology (Drs Foulke, Marks, and Clarke) and Pathology (Dr Baccon), Penn State Hershey Medical Center, Hershey, Pennsylvania.

Arch Dermatol. 2012;148(9):1100-1101. doi:10.1001/archdermatol.2012.1711

Amyopathic dermatomyositis (ADM) is a variant of dermatomyositis (DM) lacking myopathy. Though it has been argued that patients with ADM are in a “premyopathic stage” of DM, several studies show that a minority of patients with ADM develop myopathy.1-3 Failure to recognize ADM may lead to inadequate treatment and screening for DM-associated malignant neoplasm and interstitial lung disease.3 The development of weakness in ADM may not represent progression to classic DM, and a thorough evaluation is necessary to determine its cause.

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