Author Affiliations: Departments of Dermatology (Drs Foulke, Marks, and Clarke) and Pathology (Dr Baccon), Penn State Hershey Medical Center, Hershey, Pennsylvania.
Amyopathic dermatomyositis (ADM) is a variant of dermatomyositis (DM) lacking myopathy. Though it has been argued that patients with ADM are in a “premyopathic stage” of DM, several studies show that a minority of patients with ADM develop myopathy.1- 3 Failure to recognize ADM may lead to inadequate treatment and screening for DM-associated malignant neoplasm and interstitial lung disease.3 The development of weakness in ADM may not represent progression to classic DM, and a thorough evaluation is necessary to determine its cause.
Foulke G, Baccon J, Marks JG, Clarke JT. Antimalarial Myopathy in Amyopathic Dermatomyositis. Arch Dermatol. 2012;148(9):1100–1101. doi:10.1001/archdermatol.2012.1711