Sufficiency and Safety of 2-cm Excision Margin for Stage IIA Through Stage IIC Cutaneous Melanoma

Commentary on: Two-centimeter vs 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial Gillgren P, Drzewiecki KT, Niin M, et al Lancet. 2011;378(9803):1635-1642.

Question: In patients with clinical stage IIA through IIC cutaneous melanoma thicker than 2 mm, is survival different for a 2-cm local excision margin compared with a 4-cm excision margin?

Design: Randomized controlled trial. The trial was not masked at any stage.