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Oct 2012

Erythema Gyratum Repens Induced by Pegylated Interferon Alfa for Chronic Hepatitis C

Author Affiliations

Author Affiliations: Section of Dermatology, Dipartimento di Scienze della Salute, University of Genoa, Genoa, Italy.

Arch Dermatol. 2012;148(10):1213-1214. doi:10.1001/archdermatol.2012.1968

Erythema gyratum repens (ERG) is a distinctive dermatitis often associated with paraneoplastic syndrome.1 We report 2 cases of EGR associated with pegylated interferon alfa treatment for hepatitis C virus (HCV)-related chronic hepatitis.

A 47-year-old woman was seen for a pruritic skin eruption of 1 week's duration. For 10 months, she was treated with pegylated interferon alfa-2a, 180 μg/wk, and ribavirin, 800 mg/d, for chronic HCV hepatitis. She noted that the eruption generally reappeared or worsened 1 to 2 days after the weekly therapy with interferon.