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The Cutting Edge: Challenges in Medical and Surgical Therapies
Dec 2012

Successful Treatment of Recurrent Idiopathic Plantar Eccrine Hidradenitis With Colchicine

Author Affiliations
 

SECTION EDITOR: EDWARD W. COWEN, MD, MHSc; ASSISTANT SECTION EDITORS: MURAD ALAM, MD; RUTH ANN VLEUGELS, MD

Arch Dermatol. 2012;148(12):1357-1359. doi:10.1001/archdermatol.2012.2221

Idiopathic palmoplantar eccrine hidradenitis (IPPH) is a distinct clinical entity in otherwise healthy children with sudden appearance of tender, erythematous nodules on the soles or palms. Therapy usually consists of bed rest for a few days and nonsteroidal anti-inflammatory drugs (NSAIDs). However, a proportion of patients experiences recurrent episodes of IPPH, causing significant pain and limiting their daily activities. The pathogenesis of IPPH is not completely understood; however, the histologic feature consists of an inflammatory infiltrate of neutrophils and lymphocytes. Colchicine is effectively used for the treatment of classical neutrophilic skin disorders. To our knowledge, this is the first report of recurrent IPPH successfully treated with colchicine in a child.

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