A 5-year-old boy with a port-wine stain (PWS) on the left side of his face in a V1-V3 distribution, including the left frontotemporal scalp, was referred to us for treatment with an alexandrite laser. He had undergone 22 pulsed-dye laser (PDL) treatments to the entire PWS, including on the scalp, and the treatment had reached a plateau of efficacy. During the evaluation, a striking alopecia was noted on the left frontotemporal scalp in the region of the PWS (Figure). The parents reported that the patient had hair present at birth in the area of alopecia.