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April 2013

Efficacy of Lenalidomide in Refractory Lupus Pernio

Author Affiliations

Author Affiliations: Department of Immunology, Erasmus Medical Center, Rotterdam, the Netherlands.

JAMA Dermatol. 2013;149(4):493-494. doi:10.1001/jamadermatol.2013.1313

Lupus pernio is a specific sarcoidosis skin lesion characterized by violaceous indurated plaques primarily affecting the central face. It is a hallmark of chronic disease, and treatment remains challenging because conventional therapies often fail.

We describe a 57-year-old white female patient with a history of biopsy-proven sarcoidosis affecting the lungs and skin. No treatment was required for pulmonary involvement. On physical examination, a disfiguring erythematous to violaceous indurated plaque with a central crusted area was found on her nose (Figure). compatible with lupus pernio.