Author Affiliations: Department of Dermatology (Ms Surinach, Drs Bahadoran, Chiaverini, Montaudie, Passeron, and Lacour and Ms Erfan) and Service d’hémato-oncologie pédiatrique, Nice University Archet II Hospital (Dr Deville), Nice, France; Department of Dermatology, Dijon University, Bocage Hospital, Dijon, France (Dr Vabres); Groupement de Coopération Sanitaire (GCS), Centre Hospitalier Universitaire (CHU) de Nice, Lenval, France (Drs Chiaverini and Deville); Department of Pediatrics, CHU Bocage, Dijon (Dr Ben Signor); Laboratoire central d’anatomie pathologique, Nice University, Pasteur Hospital, Nice (Dr Benchetrit); and INSERM U1065 équipe, 12, C3M Hopital de l'Archet, CHU de Nice, Nice (Dr Passeron).
Langerhans cell histiocytosis (LCH) is a multisystemic disease of childhood characterized by abnormal clonal proliferation of Langerhans cells, with skin lesions often involving flexural areas. We report 2 cases of eruptive nevi seen in skin folds of children with LCH.
A 9-year-old boy with a history of LCH was referred for brown macules in the inguinal and axillary regions. He was diagnosed as having LCH at age 2 years and was treated with prednisone and vinblastine because of bone and pituitary involvement. He then developed pigmented lesions in the groin bilaterally and both axillae. Physical examination revealed small brown inguinal and axillary macules, 1 to 4 mm in diameter (Figure 1A), with a fine peripheral network and small globules on dermoscopy. Histologic examination confirmed the diagnosis of junctional nevus with spitzoid features (Figure 1B).
Surinach C, Bahadoran P, Vabres P, Chiaverini C, Montaudie H, Erfan N, Deville A, Ben Signor C, Benchetrit M, Passeron T, Lacour J. Flexural Agminated Eruptive Nevi in Langerhans Cell Histiocytosis. JAMA Dermatol. 2013;149(5):635–637. doi:10.1001/jamadermatol.2013.3299