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May 2013

Flexural Agminated Eruptive Nevi in Langerhans Cell Histiocytosis

JAMA Dermatol. 2013;149(5):635-637. doi:10.1001/jamadermatol.2013.3299

Langerhans cell histiocytosis (LCH) is a multisystemic disease of childhood characterized by abnormal clonal proliferation of Langerhans cells, with skin lesions often involving flexural areas. We report 2 cases of eruptive nevi seen in skin folds of children with LCH.

A 9-year-old boy with a history of LCH was referred for brown macules in the inguinal and axillary regions. He was diagnosed as having LCH at age 2 years and was treated with prednisone and vinblastine because of bone and pituitary involvement. He then developed pigmented lesions in the groin bilaterally and both axillae. Physical examination revealed small brown inguinal and axillary macules, 1 to 4 mm in diameter (Figure 1A), with a fine peripheral network and small globules on dermoscopy. Histologic examination confirmed the diagnosis of junctional nevus with spitzoid features (Figure 1B).

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