Brachioradial pruritus (BRP) is characterized by intractable itching localized to the dorsolateral aspects of the arms.1,2 Aprepitant (Emend; Merck & Co Inc), approved in 2003 for chemotherapy-induced nausea and vomiting, has been used successfully to treat patients with chronic pruritus,3,4 but to our knowledge, its use in BRP has not yet been reported.