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June 2013

Purpuric Eruption on the Feet of a Healthy Young Woman—Diagnosis

JAMA Dermatol. 2013;149(6):751-756. doi:10.1001/jamadermatol.2013.3314h

Histopathologic examination revealed a dense superficial and deep perivascular lymphocytic infiltrate with extravasated red blood cells (RBCs) (Figure 2 and Figure 3) and rare eosinophils. Frank vascular wall injury was not seen, although some of the endothelial cells were enlarged. Direct immunofluorescence findings for IgM were weakly positive in several superficial dermal vessels, with additional focal background staining of C3. Results of Gram and Grocott-methenamine staining were negative for organisms.

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