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JAMA Dermatology Clinicopathological Challenge
September 2013

Umbilicated Facial Papules in an Immunosuppressed Patient

Author Affiliations
  • 1University of California, San Diego, School of Medicine, La Jolla
  • 2Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, New York
  • 3Department of Dermatopathology, Columbia University, College of Physicians and Surgeons, New York, New York
JAMA Dermatol. 2013;149(9):1101-1102. doi:10.1001/jamadermatol.2013.353

A 50-year-old woman of Trinidadian descent presented with a 2-week history of asymptomatic, umbilicated, skin-colored facial papules. She had been diagnosed 2 years previously with human T-cell lymphotrophic virus type 1 (HTLV-1)–associated adult T-cell leukemia/lymphoma (ATLL). Since then, she had been treated with multiple chemotherapy regimens, but the only one eliciting a partial response was ICE (ifosfamide, carboplatin, and etoposide). However, she eventually experienced relapse, as confirmed by bone marrow biopsy.

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