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Invited Commentary
Practice Gaps
March 2014

Understanding How Cutaneous Lupus Erythematosus Progresses to Systemic Lupus Erythematosus

Author Affiliations
  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas
JAMA Dermatol. 2014;150(3):296. doi:10.1001/jamadermatol.2013.9030

Epidemiological studies have reported that up to 23% of patients with cutaneous lupus erythematosus (CLE) develop systemic lupus erythematosus (SLE), with some progressing over several years.1 As these data have been important in estimating one’s risk of systemic spread, how CLE progresses to SLE in these patients is unknown. This article by Wieczorek et al2 seeks to address this practice gap by evaluating the severity of symptoms and SLE criteria that are seen and met in patients with CLE who develop SLE.