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January 1998

Perforating Papules in Chronic Renal Failure

Author Affiliations


Arch Dermatol. 1998;134(1):97-102. doi:

A 27-year-old, human immunodeficiency virus–negative white man with an 8-year history of Wegener granulomatosis underwent a frontal sinus biopsy after severe recurrent nose bleeding. The patient's condition remained stable on a regimen of cyclophosphamide and prednisone for approximately 2 years until laboratory tests revealed that his serum urea nitrogen and creatinine levels were elevated; the results of a renal biopsy confirmed a diagnosis of Wegener granulomatosis. Peritoneal dialysis was subsequently initiated 2 years before the patient presented with a skin eruption. Other significant medical history included arthritis, hypertension, anemia due to chronic renal failure and chronic disease, cytomegalovirus colitis, herpes zoster infection with associated encephalitis, and testicular leiomyoma.