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February 1998

Papular-Purpuric ‘Gloves and Socks' Syndrome Associated With Human Herpesvirus 6 Infection

Arch Dermatol. 1998;134(2):242-244. doi:

The descriptive term papular-purpuric gloves and socks syndrome (PPGSS) was coined by Harms et al1 in 1990. Until now, 24 cases have been reported worldwide.1-7 The patients show sharply marginated pruritic and/or painful erythema, edema, and small, flat papules in a symmetrical gloves-and-socks distribution with rapid development of petechial purpura. Prodromal signs (fatigue, anorexia, and sudden onset of fever) have been reported. The mucosal involvement consists of enanthema with small erosions and vesicles.