In a recent issue of the ARCHIVES, McCormack et al1 describe patients with superficial basal cell carcinoma (BCC) who had a significantly lower mean age at diagnosis than those with other subtypes and that 73.3% of superficial BCCs occur on the trunk.1 We have investigated the role of polymorphism in various detoxifying enzymes on the risk of BCC. In particular, we have assessed the role of glutathione S-transferases (GST, GSTM1, and GSTT1).2-4 These are good candidates for BCC pathogenesis since they play a role in the defense against UV-induced oxidative stress damage to the skin.2,3
Lear JT, Smith AG, Strange RC, Fryer AA. Patients With Truncal Basal Cell Carcinoma Represent a High-Risk Group. Arch Dermatol. 1998;134(3):373. doi:https://doi.org/10.1001/archderm.134.3.373
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